DISULFIRAM-INDUCED ACETONEMIA IN RAT AND MAN

  • 1 January 1977
    • journal article
    • research article
    • Vol. 18  (2) , 361-364
Abstract
Disulfiram treatment caused marked elevations of circulating blood acetone levels in rat and man. In the rat, disulfiram (0.59 g/kg, p.o [orally]) given singly or for 3 consecutive days increased fasting blood acetone levels 5- and 25-fold, respectively. Circulating acetone levels were estimated noninvasively in man by measuring acetone in the expired air. A 15-fold increase in expired air acetone levels was observed in a group of 5 male non-fasting subjects taking disulfiram (250 mg daily) for a minimum of 1 mo., when compared to control subjects.

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