Human muscle pyruvaite dehydrogenase activity
- 1 January 1983
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 33 (1) , 51
- https://doi.org/10.1212/wnl.33.1.51
Abstract
Muscle pyruvate dehydrogenase complex (PDHC) activity was studied in 70 patients with different neuromuscular disorders. Children had higher total PDHC and lipoamide dehydrogenase (LAD) activities than adults. There were no significant differences in muscle PDHC activity in patients with Friedreich ataxia, patients with other ataxias, or age-matched controls. Kinetic analysis of LAD showed no differences in Km for lipoamide between Friedreich ataxia patients and controls.This publication has 8 references indexed in Scilit:
- Friedreich ataxiaNeurology, 1982
- Pyruvate Decarboxylase Deficiency in Subacute Necrotizing EncephalomyelopathyArchives of Neurology, 1981
- Clinical correlations of partial deficiency of lipoamide dehydrogenaseNeurology, 1979
- Friedreich ataxiaNeurology, 1979
- Regulation of the Human Pyruvate Dehydrogenase ComplexClinical Science, 1976
- Glucose metabolism in perfused skeletal muscle. Pyruvate dehydrogenase activity in starvation, diabetes and exerciseBiochemical Journal, 1976
- Low Activities of the Pyruvate and Oxoglutarate Dehydrogenase Complexes in Five Patients with Friedreich's AtaxiaNew England Journal of Medicine, 1976
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951