Fatal Relapse of Coccidioidomycosis Ten Years after Treatment with Amphotericin B

Abstract
SINCE the introduction of amphotericin B for parenteral administration in 1957, there have been numerous reports of its success in the treatment of patients with disseminated coccidioidomycosis.1 , 2 Treatment failures have generally been due to primary drug failures or relapse within a short time of therapy.2 3 4 The effect of amphotericin B on the tendency to late relapse in patients with disseminated coccidioidomycosis is not known. This case report, documenting relapse 10 years after apparently successful therapy, emphasizes the necessity for lifelong follow-up observation of treated patients.Case ReportL.D., a 53-year-old Negro, entered the hospital on December 4, 1968, because of . . .

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