Small Molecule Natural Products in the Discovery of Therapeutic Agents: The Synthesis Connection
Top Cited Papers
- 3 August 2006
- journal article
- review article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 71 (22) , 8329-8351
- https://doi.org/10.1021/jo0610053
Abstract
Natural products have been a rich source of agents of value in medicine. They have also inspired, at various levels, the fashioning of nonnatural agents of pharmaceutical import. Hitherto, these nonnatural derivatives have been primarily synthesized by manipulating the natural product. As a consequence of major innovations in the subscience of synthetic methodology, the capacity of synthesis to deal with molecules of considerable complexity has increased dramatically. In this paper, we show by example some total syntheses which draw from strategy-enabling advances in methodology. Moreover, we show how these capabilities can be used to discover and develop new agents of potential pharmaceutical value without recourse to the natural product itself.Keywords
This publication has 126 references indexed in Scilit:
- Torsional Steering Controls the Stereoselectivity of Epoxidation in the Guanacastepene A SynthesisOrganic Letters, 2006
- Proteasome Inhibition by a Totally Synthetic β-Lactam Related to Salinosporamide A and OmuralideJournal of the American Chemical Society, 2005
- Natural Products as Sources of New Drugs over the Period 1981−2002Journal of Natural Products, 2003
- Regio- and Enantioselective Cyclization of Epoxy Alcohols Catalyzed by a [CoIII(salen)] ComplexAngewandte Chemie International Edition in English, 1999
- THE α-ALKYLATION OF ENOLATES FROM THE LITHIUM-AMMONIA REDUCTION OF α,β-UNSATURATED KETONESJournal of the American Chemical Society, 1961
- A NEW ALKYLATION OF CARBONYL COMPOUNDS. II1Journal of the American Chemical Society, 1956
- A NEW SYNTHESIS OF 2-ALKYL AND 2-ACYL KETONESJournal of the American Chemical Society, 1954
- “Enamine” Derivatives of Steroidal Carbonyl Compounds. IIJournal of the American Chemical Society, 1953
- STEREOSPECIFIC TOTAL SYNTHESIS OF CORTISONEJournal of the American Chemical Society, 1952
- The Total Synthesis of Steroids1Journal of the American Chemical Society, 1952