Experimental Allergic Encephalomyelitis in the Chicken

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Abstract
Summary: Signs, symptoms and CNS histological lesions of EAE can be induced in chickens suitably injected with chicken CNS in Freund's adjuvants. Chicken cerebrum is less active and chicken cerebellum is inactive, in contrast to chicken spinal cord as the inoculum. There is a striking difference in reaction between two breeds of chickens. White Leghorns develop disseminated CNS lesions without displaying CNS signs and symptoms, whereas White Rocks develop both clinical and histological evidence of EAE. Chickens may recover from severe CNS signs and symptoms despite the continued persistence of severe CNS lesions. The demonstration that this nonmammalian host can be used in EAE studies, together with the genetic and other differences in reaction pointed out above, affords several additional and new possibilities for investigation. These include antibody studies in ovo and in hatchlings from inoculated fertilized hens, studies in a host with higher body temperature and metabolic rate than the usual laboratory mammals employed, studies of the influence of genetics via crossbreedings between White Rocks and White Leghorns, and studies in the induction of clinical relapse in asymptomatic but CNS lesion-bearing birds.

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