Effect of 1,25-dihydroxyvitamin D deficiency on the metabolic clearance rate of 1,25-dihydroxyvitamin D3: studies using pigs with vitamin D-dependent rickets type 1
- 1 November 1985
- journal article
- research article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 69 (5) , 549-552
- https://doi.org/10.1042/cs0690549
Abstract
1. We have used pigs with inherited vitamin D-dependent rickets type 1 to study the effect of 1,25-dihydroxyvitamin D deficiency on the metabolic clearance rate of 3H-1,25-dihydroxy-vitamin D3 infused to steady-state levels in plasma. 2. Plasma levels of 1,25-dihydroxyvitamin D were 24 .+-. 1 (SEM) pmol/l in the hypocalcaemic, homozygous piglets and 196 .+-. 27 pmol/l in their normocalcaemic, heterozygous siblings. 3. The metabolic clearance rate of 1,25-dihydroxyvitamin D3 was the same in both normal heterozygous (0.90 .+-. 0.02) and hypocalcaemic, homozygous piglets (0.90 .+-. 0.01 ml-1 min-1 kg-1 metabolic bodysize). 4. We conclude that a deficiency of circulating 1,25-dihydroxyvitamin D does not influence the clearance of 1,25-dihydroxyvitamin D3 from the circulation of pigs.This publication has 0 references indexed in Scilit: