ABO Hemolytic Disease of the Newborn

Abstract
The charts of newborn infants with positive direct Coombs' test were studied. Only cases in which the mother's blood was group O and the infant's group A or group B were studied. There was no difference between group A and group B infants in the frequency and severity of the hemolytic process caused by maternal antibodies. In group B infants, monospecific antibodies (anti-B) were associated with more severe hemolyticprocess than cross-reacting antibodies (anti-A,B). In group A infants there was no difference in the severity of the disease between monospecific antibodies (anti-A) and cross-reacting antibodies (anti-A,B). Even though there was no significant difference in the sex distribution of affected infants, there was a higher number of boys in the more severely affected group.

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