Latent renal tubular acidosis in Sjøgren's syndrome.

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Abstract
In 10 nonazotemic patients with Sjogrren''s syndrome, renal acidification and concentration were evaluated and compared with those in 21 normal subjects. Although no overt acid-base imbalance was present in any subject, in 3 patients the renal response to the administration of an acute acid load was inadequate, and renal concentrating capacity was slightly impaired. These findings are consistent with latent renal tubular acidosis. Thus, it appears that renal tubular acidosis, the detection of which may be facilitated by an acid loading test, may be an occasional feature of Sjogren''s syndrome. The cause of renal tubular acidosis and its possible relationship to hypergammaglo-bulinaemia are discussed.