Acceleration of Growth in Two Children Treated with Human Growth Hormone-Releasing Factor
- 3 January 1985
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 312 (1) , 4-9
- https://doi.org/10.1056/nejm198501033120102
Abstract
Two growth hormone–deficient children were treated with growth hormone–releasing factor for six months. The pattern of administration — 1 to 3 μg per kilogram of body weight, given subcutaneously over one minute every three hours by infusion pump — was chosen to simulate growth hormone secretion in normal children. During the first week of therapy, both children had evidence of the metabolic effects of increased growth hormone secretion — i.e., nitrogen retention, demonstrated by decreased nitrogen excretion (P<0.05), and increased urinary calcium excretion (P<0.01).This publication has 17 references indexed in Scilit:
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