Syntheses of the Amides Derived from Heterocyclic Acids and Heterocyclic Amines and Their Antitumor Activities
Open Access
- 1 January 1976
- journal article
- research article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 96 (4) , 471-474
- https://doi.org/10.1248/yakushi1947.96.4_471
Abstract
By the fusion method, 16 kinds of amide-type compounds were synthesized from the phenyl esters of heterocyclic acids and heterocyclic amines, and their antitumor activities were examined with Ehrlich ascites carcinoma and Crocker sarcoma-180 in mice. None had a strong antitumor activity but 7 of the test compounds, 2-isonicotinoylamino-1,3,4-thiadiazole, 2-nicotinoylamino-5-isopropyl-1,3,4-thiadiazole, 2-isonicotinoylamino-5-isopropyl-1,3,4-thiadiazole, 2-(.alpha.-thenoylamino)-5-isopropyl-1,3,4-thiadiazole, 2-(.alpha.-furoylamino)-5-isopropyl-1,3,4-thiadiazole, 2-isonicotinoylamino-5-isobutyl-1,3,4-thiadiazole and 2-(.alpha.-furoylamino)-5-isobutyl-1,3,4-thiadiazole, had a moderate to slight antitumor activity against these solid tumors. All these effective compounds were the derivatives of 2-amino-1,3,4-thiadiazole.This publication has 0 references indexed in Scilit: