Inhibitory effect of cephalosporins on gamma-aminobutyric acid receptor binding in rat synaptic membranes
- 1 April 1985
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 27 (4) , 650-651
- https://doi.org/10.1128/aac.27.4.650
Abstract
Cephalosporins inhibited gamma-aminobutyric acid receptor binding in a concentration-dependent manner in vitro. Scatchard analysis revealed that cefazolin decreased the binding capacity but did not change the affinity of the receptor. It is suggested that this inhibition of gamma-aminobutyric acid receptor binding may be involved in the induction of convulsions by cephalosporins.Keywords
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