Catalase and the production of brain acetaldehyde: a possible mediator of the psychopharmacological effects of ethanol
- 1 July 1997
- journal article
- Published by Wiley in Addiction Biology
- Vol. 2 (3) , 277-290
- https://doi.org/10.1080/13556219772570
Abstract
This review represents an attempt to assess the available data on the role of catalase in the mediation of the behavioral actions of ethanol and the regulation of voluntary ethanol consumption. It is argued that acetaldehyde may be formed in brain through the peroxidatic activity of catalase. Furthermore, acetaldehyde formed centrally through the activity of this enzyme, may be responsible, at least in part, for some of the motivational, behavioral and neurotoxic effects of ethanol.Keywords
This publication has 73 references indexed in Scilit:
- The nitric oxide synthase inhibitor NW-Nitro-L-Arginine methylester attenuates brain catalase activity in vitroLife Sciences, 1995
- New Perspectives in Catalase Dependent Ethanol MetabolismDrug Metabolism Reviews, 1989
- Red blood cells: A new major modality for acetaldehyde transport from liver to other tissuesLife Sciences, 1987
- Blockade of ethanol induced conditioned taste aversion by 3-amino-1,2,4-triazole: Evidence for catalase mediated synthesis of acetaldehyde in rat brainLife Sciences, 1985
- Ethanol preference in rats with a prior history of acetaldehyde self-administrationCellular and Molecular Life Sciences, 1984
- Intraventricular self-administration of acetaldehyde and voluntary consumption of ethanol in ratsBehavioral and Neural Biology, 1980
- Biphasic action of ethanolBiobehavioral Reviews, 1978
- Separation of aldehyde reductases and alcohol dehydrogenase from brain by affinity chromatography: Metabolism of succinic semialdehyde and ethanolBiochemical and Biophysical Research Communications, 1975
- ALCOHOL DEHYDROGENASE ACTIVITY IN RAT BRAIN AND LIVERJournal of Neurochemistry, 1970
- The reaction between aminotriazole and catalaseBiochimica et Biophysica Acta, 1962