Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence
- 1 January 1991
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 349 (6307) , 305-310
- https://doi.org/10.1038/349305a0
Abstract
Voltage-dependent potassium, sodium and calcium ion channels may share a common mechanism of activation, in which the conserved S4 sequence acts as the primary voltage sensor. Site-directed mutagenesis of the S4 sequence of the Shaker potassium channel and electrophysiological analysis suggest that voltage-dependent activation involves the S4 sequence but is not solely due to electrostatic interactions.Keywords
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