Transretinal Electrical Stimulation with a Suprachoroidal Multichannel Electrode in Rabbit Eyes

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Abstract
A flat electrode array (polyimide plate, platinum electrode) was developed and used for this study. After performing a scleral incision at 2–2.5 mm from the limbus and placing an anchoring suture, the array was inserted into the suprachoroidal space in the posterior portion of the eye by direct observation under a microscope. A platinum wire was implanted into the vitreous space as a reference electrode. For electrical stimulation, a biphasic pulse was used. When the electrode was stimulated, the EEP was recorded. When the electrical stimulation from the suprachoroidal space was applied, the EEP could be recorded with an epidural electrode, and the threshold was 66.0 ± 32.1 µA (42.0 µC/cm2). Histological examination indicated the absence of major damage to the retina and choroid from the insertion and placement of the array and the electrical stimulation. Transretinal electrical stimulation from the suprachoroidal space could elicit EEP, suggesting that this approach may be useful for a retinal prosthesis system. Jpn J Ophthalmol 2004;48:256–261 © Japanese Ophthalmological Society 2004

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