THE EFFECT OF IODOCHLORO-OXYQUINOLINE AND IOPANOIC ACID ON THE DETERMINATION OF PBI AND BEI

Publisher Website
Google Scholar
Abstract
The results confirm that BEI [butanol extractable iodine] determination is a more specific method than PBI [protein-bound iodine] determinatioi for the estimation of the concentration of thyroxine and other, if any, Iodine-containing hormones. Although the adminstration of lodinated organic compounds sometimes Increased the BEI concentration, the latter in this respect was less susceptible than the PBI. Ingestion of iodochloro-oxyquinoline to a small number of healthy volunteers caused both the PBI and the BEI concentration to reach higher values than could be determined by the methods used. Following discontinuation of intake the BEI level required only one week to return to the normal range; the PBI, however, took several weeks. Administration of lopanoic acid (for cholecystography) caused a much greater and more prolonged increase in PBI than in BEI.