Hyperplasia of the Adrenal Medulla

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Abstract
The theoretical possibility of adrenal medullary hyperplasia exists, but no cases have been described up to now. Recently a case was encountered in which the signs and symptoms suggested a pheochromocytoma. The usual diagnostic tests were positive. At surgical exploration unilateral adrenal medullary hyperplasia was found. Removal of the hyperplastic gland resulted in amelioration of signs and symptoms. Previously positive phentolamine, histamine, and catechol amine responses could not be duplicated after operation. Hyperfunctioning adrenal medullary hyperplasia does exist, therefore, and the authors believe that in those instances in which exploration for pheochromocytoma reveals no tumor, bilateral medullary biopsy should be performed.

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