Experimental Alteration of the Ability of Tumor Cells to Lyse Plasma Clots in vitro

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Abstract
Mouse sarcoma 180 cells, in the presence of mammalian serum, cause lysis of chicken plasma clots. This lytic process is only slightly affected by mammalian aqueous humor but is inhibited by the addition of avian sera. Lysis does not occur when mammalian serum previously heated at 56[degree] C. for 3 hrs. is employed or when all mammalian serum is omitted from the supernatant medium of the tissue culture prepn. The inhibitory effect of avian sera on the lytic activity of various mammalian sera when in the presence of mammalian tissue may be tentatively explained by assuming that mammalian tissue kinase reacts with mammalian serum profibrinolysin to form an active fibrinoly-sin whereas mammalian kinase reacts with avial profibrinolysin to form an inactive complex. The different degrees of lysis obtained when sera from various mammalian orders are used may be due to differences in the amt. of profibrinolysin in the various sera. It is clear that both a tissue factor and a plasma or serum factor are invplved in the lysis of chicken plasma clots.

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