Determination of Benazepril and Cilazapril in Pharmaceuticals by High Performance Liquid Chromatography
- 1 July 1997
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography & Related Technologies
- Vol. 20 (13) , 2135-2142
- https://doi.org/10.1080/10826079708005571
Abstract
A high performance liquid chromatography method was developed for the specific determination of new angiotensin-converting enzyme inhibitors benazepril and cilazapril in pharmaceutical dosage forms. The proposed method was conducted using a reverse phase technique, UV monitoring at 211 nm and enalapril as an internal standard. The detector response was linear in the range of 10–50 μg/mL for benazepril and 40–200 μg/mL for cilazapril. The drugs were extracted from tablets with methanol. The percentage recoveries ranged from 96.34 to 102.04 and from 103.08 to 107.96 for benazepril and cilazapril, respectively.Keywords
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