ALLOTYPE SYNTHESIS BY ADULT DONORS?? LEUKOCYTES AND SPLEEN CELLS INJECTED INTO NEWLY HATCHED CHICKS

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Abstract
SUMMARY A model for detecting donor cells in chimeric chickens, utilizing genetically determined allotypes, was presented. Results indicated that: (1) donor cells functioned in their new milieu for at least. 13 months for leukocytes and 6 months for spleen cells: (2) donor allotype, when found in recipient sera, occasionally reached levels comparable to those found in donor-type individuals; (3) cells found in the blood of a chimera 2 months after initial transfer of spleen cells were still capable of inducing tolerance and producing original donor allotype when retransferred to newly hatched chicks. Differences in persistence of tolerance because of number and type of cell used, temporary disappearance of donor allotype, and possible use of Fi cells to improve the performance of inbred animals were investigated and discussed.

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