Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder
- 1 December 2006
- journal article
- clinical trial
- Published by Cambridge University Press (CUP) in European Psychiatry
- Vol. 21 (8) , 544-547
- https://doi.org/10.1016/j.eurpsy.2005.04.003
Abstract
Purpose: The effect of methylphenidate (MPH) on inhibitory control as assessed by the stop task in children with attention-deficit/hyperactivity disorder (ADHD) could be influenced by task difficulty and may be mediated by attention.Subjects and methods: Fifteen children with ADHD performed the stop and the change task after placebo, 0.5 and 1.0 mg/kg MPH in a within-subject design.Results: Linear-trend analysis showed a similar effect of MPH in both tasks and a stronger effect for inhibitory control than for attention. Furthermore, a correlation was found between blood serum metabolites of norepinephrine and dopamine for attentional measures and inhibitory control measures, respectively.Discussion and conclusion: In children with ADHD MPH could act primarily on inhibitory control, and is not influenced by task difficulty. Also, attention and inhibitory control could have differential pharmacological profiles.Keywords
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