Unstable Triplet Repeat Diseases
- 15 January 1995
- journal article
- review article
- Published by Wolters Kluwer Health in Circulation
- Vol. 91 (2) , 513-520
- https://doi.org/10.1161/01.CIR.91.2.513
Abstract
Abstract Seven inherited human disorders are now associated with the intragenic expansion of triplet repeat DNA sequences. These repeats demonstrate extreme instability in both germline and somatic tissue, accounting for the unusual genetic inheritance patterns and symptom variability associated with these diseases.Keywords
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