The Effect of Sulphydryl and Enzyme Inhibitors on Platelet Aggregation in Vitro
- 1 January 1966
- journal article
- research article
- Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis
- Vol. 16 (01/02) , 122-133
- https://doi.org/10.1055/s-0038-1655632
Abstract
Summary: The glycolytic enzyme poisons potassium cyanide, sodium fluoride, and monofluoroacetate do not inhibit platelet clumping. The sulphydryl inhibitors, n-ethyl maleimide and p-hydroxymercuribenzoate, inhibit platelet aggregation produced by ADP, ATP, nor-adrenaline, 5HT, thrombin and connective tissue extract. This inhibitory activity is counteracted by 1-cysteine. These results suggest that platelet thiol groups are involved in the platelet adhesion occurring during aggregation.This publication has 9 references indexed in Scilit:
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