Isolation and characterization of cardiac steroids from seeds of Elaeopendron glaucum Pers. Structures of elaeodendrosides A,D,E,H,I,J and elaeodendrogenin.

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Abstract
Six cardiac glycosides having a methylenedioxy group in the sugar moiety, elaeodendroside A, D, E, H, I and J, were isolated from seeds of E. glaucum Pers. Their structures were elucidated on the basis of chemical correlation with elaeodendroside A, which was characterized by X-ray analysis. A new cardiac steroid named elaeodendrogenin was also isolated from the same plant materials and its structure was established by direct comparison with a synthetic sample obtained from digitoxigenin. The cardiac activities of these compounds were tested with Straub''s preparation [isolated frog heart].