Assessment of the response to chemotherapy in oesophageal cancer

Abstract
Thirty-eight patients with localised oesophageal carcinoma have beenstudied by computed tomography (CT) and barium swallow before and afterpreoperative chemotherapy and the results correlated with the pathologicalfindings in the resected specimen. Overall 48% of patients showed acomplete or partial response to chemotherapy on CT, compared with 50% onbarium and 94% on pathological examination. This study highlightsdeficiencies in CT scanning and barium swallow as methods of assessing theregression of tumor bulk following chemotherapy for oesophageal carcinoma.We suggest that strict and specific criteria will have to be laid downbefore the results of chemotherapy in this disease can be reliably andaccurately evaluated.

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