Effects of Hydration on Blood and Cerebrospinal Fluid Osmolalities

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Abstract
Summary The CSF and serum osmolalities have been studied by the Fiske freezing-point depression method in dehydrated cats undergoing rapid hydration. In the initial baseline dehydrated state the CSF is hypertonic to blood by 4.3 mOsm on the average. During hydration the osmolality of both fluids fell but the CSF osmolality changes lagged behind changes in blood osmolality. The lag in CSF osmolality was quite variable but averaged between 45 and 65 min, depending upon the method of estimating it. When blood osmolality started to rise, there was often a transient period of CSF hypotonicity to blood. These findings can be attributed to the large inter-capillary distances existing in the CSF compartment as compared to brain.

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