Investigation of thermoregulatory characteristics in patients with Prader‐Willi syndrome

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Abstract
A survey instrument is used to assess temperature regulation characteristics in children with Prader‐Willi syndrome (PWS) compared to 3 control groups: sibs of PWS patients (SIB), neurodevelopmentally handicapped children (ND), and age and gender matched well children (WC). Significant differences were found between PWS patients, SIB controls, and WC controls in the prevalence of febrile convulsions, fever‐associated symptoms, and temperature less than 94°F. No differences were noted in any variable between the PWS patients and the ND controls, suggesting that these abnormalities are not unique to PWS, but can occur in any neurodevelopmentally handicapped individual, further suggesting these do not necessarily reflect syndromespecific hypothalamic abnormalities.