2-(6-Carboxyhexyl)cyclopentanone hexylhydrazone. A potent and time-dependent inhibitor of platelet aggregation

Publisher Website
Google Scholar
Abstract
Two new azaprostanoids, a hydrazone [2-(6-carboxyhexyl)cyclopentanone hexylhydrazone] (3) and hydrazide [2-(6-carboxyhexyl)cyclopentylidenecaproic acid hydrazide] (4), were prepared by the condensation of 2-(6-carboxyhexyl)cyclopentanone with n-hexylhydrazine and caproic acid hydrazide. Preliminary results with the stable hydrazide 4 indicate that it inhibits arachidonic acid(AA)-induced human platelet aggregation and that, unlike 13-azaprostanoic acid (1), its site of action is at the cyclooxygenase level. Results with the unstable hydrazone derivative 3 indicate it to be a potent and time-dependent inhibitor of AA-induced human platelet aggregation, with its site of action also at the cyclooxygenase level.