The Significance of Acidosis in Certain Nervous Disorders

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Abstract
The clinical evidence of acidosis is the detection of acetone bodies in the urine. Acetone is formed from diacetic acid by the splitting off of carbonic acid, the origin of diacetic acid being in part from fats and in part from proteins. Oxybutyric acid is also formed from diacetic acid by reduction, consequently the presence of acetone bodies in the urine always means that acidosis is taking place. A delicate test is that known as Rothera's, which is quite simple, and will detect acetone in minute dilution:

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