Phytohemagglutinin and Hematopoietic Stem Cells in the Mouse

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Abstract
Administration of phytohemagglutinin to protein-fasted and polycythemic mice results in a striking increase of spleen response to erythropoietin. An opposite ef- s feet was found in bone marrow. In transplant experiments, treatment of prospective cells donors with phytohemagglutinin produces a substantial increase of the cloning efficiency of the spleen cells with little if any effect on bone marrow cells. Results of this study also demonstrate a good correlation between the time course of cytomorphological changes induced by phytohemagglutinin on spleen lymphocytes and increase of hemopoietic stem cell concentration in this organ.

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