MISCELLANY

6 July 1957

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 164 (10) , 1151-1152
https://doi.org/10.1001/jama.1957.02980100107019

Abstract

CLINICAL USE OF TOLBUTAMIDE IN DIABETES MELLITUS A STATEMENT BY THE AMERICAN DIABETES ASSOCIATION Tolbutamide (Orinase), a hypoglycemic agent for oral use, recently has been released by the Food and Drug Administration and is being generally distributed for use by prescription. This statement by the American Diabetes Association confirms in virtually every detail the editorial which appeared in a recent issue ofThe Journal.¹Members of the medical and allied professions should be fully informed concerning this new drug. It is a sulfonylurea compound with the empirical formula C₁₂H₁₈N₂O₃S. It lowers the blood sugar level of normal animals and man and of some, but not all, diabetic patients. The mechanism involved is still unknown, but it seems clear that it is ineffective in the complete absence of insulin; hence, it cannot be considered a true substitute for insulin. According to the

Keywords

This publication has 0 references indexed in Scilit: