Pressure-volume curves of systemic and pulmonary circuit

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Abstract
Mean systemic pressure (MSP) and mean pulmonary pressure (MPP) were measured in 8 mongrel dogs immediately after acute changes in blood volume. A decrease in blood volume of only 12% decreased MPP to 0 mm Hg and decreased MSP to only 2 mm Hg. From the control value of 6.4 mm Hg for MSP, an addition of 6.4 mm Hg was observed for each increase in blood volume of 18%. MPP rose from its control value of 9.9 mm Hg by an additional 9.9 mm Hg for each 12% increase in blood volume. Thus, the pressure-volume curves for the systemic and pulmonary circulation are very steep indeed. Small changes in blood volume can result in significant changes in hemodynamics. Reflexes tend to minimize these effects.

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