SINUSOIDS IN HUMAN CIRRHOTIC NODULES - BETTER IDENTIFICATION WITH THE PERFUSION FIXATION TECHNIQUE

  • 1 January 1985
    • journal article
    • research article
    • Vol. 17  (2) , 279-286
Abstract
Liver biopsies of 2 alcoholic patients with nodular cirrhosis were fixed by perfusion. Sinusoids, sinusoidal cells and the Disse space were well identified in the nodules. Compared to a normal liver biopsy, the following abnormalities were found; a larger Disse space containing fibrillar material and numerous collagen bundles, the extension of the lateral recesses between hepatocytes, the presence of a basement membrane-like material beneath thick and irregular endothelial cells, the transformation of persinusoidal cells into transitional cells and myofibroblasts-like cells. In addition perisinusoidal processes were clearly identified; they were thick, often containing numerous filaments, and displayed in 2 or more layers underlined by a discontinuous basement membrane-like material.