Localization of Human Blood to Basophils

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Abstract
Summary Human peripheral leukocytes from 15 subjects were separated into two fractions. One fraction contained most of the basophils and very few eosinophils. The other fraction contained all or almost all of the eosinophils but few basophils. The neutrophils were distributed in a random fashion between the two fractions. The histamine in each fraction was measured and found to correlate only with the basophil leukocytes. Variations of eosinophil distribution had no effect on histamine levels. Lysis of neutrophils produced only minimal amounts of histamine. These results demonstrate that histamine found in human peripheral leukocytes is localized to the basophil leukocytes.

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