Antitumor Agents, 112. Emarginatine B, a Novel Potent Cytotoxic Sesquiterpene Pyridine Alkaloid from Maytenus emarginata
- 1 March 1990
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 53 (2) , 422-428
- https://doi.org/10.1021/np50068a021
Abstract
A new sesquiterpene pyridine alkaloid, emarginatine B [2] has been isolated, along with maytansine [3], from Maytenus emarginata. Emarginatine B showed potent cytotoxicity against human KB cells (EC50 = 0.4 .mu.g/ml). Spectral correlations established its structure as a 9-benzoate and C-8 epimer of emarginatine A [1]. The conformational aspect of the latter compound was elucidated by nmr studies, including the use of 2D-nmr techniques and difference nOe methods.This publication has 6 references indexed in Scilit:
- Polyhydroxyagarofuran derivatives from Tripterygium wilfordii H.Phytochemistry, 1987
- Acanthothamine, a sesquiterpenoid alkaloid from Acanthothamnus aphyllusPhytochemistry, 1986
- New macrolide sesquiterpene alkaloids of Catha edulis: examples containing a novel dilactone bridgeJournal of the Chemical Society, Perkin Transactions 1, 1986
- Alkaloids of Catha edulis. Part 3. Structures of cathedulins K1, K2, K6, and K15; new Macrolide-bridged polyesters of euonyminolJournal of the Chemical Society, Perkin Transactions 1, 1979
- Tumor inhibitors. 122. The maytansinoids. Isolation, structural elucidation, and chemical interrelation of novel ansa macrolidesThe Journal of Organic Chemistry, 1977
- Isolation and structures of euonymine and neoeuonymine, alkaloids from Euonymus Sieboldiana blumeTetrahedron, 1977