An endogenous redox molecule, thioredoxin, regulates transactivation of epidermal growth factor receptor and activation of NF‐κB by lysophosphatidic acid
- 31 January 2001
- journal article
- Published by Wiley in FEBS Letters
- Vol. 489 (2-3) , 134-138
- https://doi.org/10.1016/s0014-5793(01)02094-4
Abstract
Lysophosphatidic acid (LPA) is the smallest and simplest of all the glycerophospholipids that activates a specific GTP‐binding protein coupled receptor to evoke multiple cellular responses. In this paper, we have demonstrated that LPA stimulates nuclear factor (NF)‐κB‐dependent gene induction in a neuronal cell line, NG108‐15 and that this is under redox regulation by an endogenous molecule, thioredoxin. We also have shown that redox‐sensitive transactivation of epidermal growth factor receptor by LPA confers NF‐κB activation and small GTPase proteins are involved in this pathway.Keywords
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