Effect of vitamin A compounds on the covalent binding of benzo(a)pyrene to nuclear macromolecules.
Open Access
- 1 January 1981
- journal article
- research article
- Published by Center for Academic Publications Japan in Journal of Nutritional Science and Vitaminology
- Vol. 27 (1) , 33-41
- https://doi.org/10.3177/jnsv.27.33
Abstract
Effect of vitamin A compounds on the covalent binding of benzo (a) pyrene [B (a) P] to subnuclear components was studied using rat liver nuclei in vitro. The retinol-induced inhibition of the covalent binding of B (a) P depended both on the dose and the time of addition. Retinal and retinyl acetate were both potent inhibitors, but retinoic acid was less effective. Retinol induced marked inhibition of B (a) P binding to DNA and protein of the nuclear matrix but had little or no effect on the labeling of bulk DNA and protein in chromatin fractions.Keywords
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