Evolution of MHC class I genes in higher primates
- 1 August 1996
- journal article
- review article
- Published by Wiley in Immunology & Cell Biology
- Vol. 74 (4) , 349-356
- https://doi.org/10.1038/icb.1996.62
Abstract
The classical major histocompatibility complex (MHC) class I genes are conserved in higher primates. Motifs common to human, chimpanzee and gorilla alleles indicate that class I alleles diverged from ancestral sequences that existed before separation of these species. Analysis of native human populations such as Australian Aborigines and Amerindians shows that HLA-B is characterized by rapid generation of new alleles. HLA-A and -C appear to be evolving more slowly. Comparison of alleles for orthologous class I genes in humans and other primates confirms that similar mechanisms contribute to the generation of new alleles in these species.Keywords
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