First Synthesis of 1-Trichloromethyl-6,7-dihydroxytetrahydroisoquinoline — An Imaginable Chloral-derived Mammalian Alkaloid

1 January 1987

journal article
research article
Published by The Japan Institute of Heterocyclic Chemistry in HETEROCYCLES

Vol. 26 (10) , 2587-2590
https://doi.org/10.3987/r-1987-10-2587

Abstract

1-Trichloromethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (3c), a potential condensation product from dopamine (1) and chloral (2c), could be prepared for the first time, by a stepwise Bischler-Napieralski pathway, and, more directly, under special Pictet-Spengler conditions. The results indicate that 3c is not a probable alkaloid in man.

Keywords

HETEROCYCLES

This publication has 1 reference indexed in Scilit:

Chemische Mechanismen der Alkohol-Wirkung
The Science of Nature, 1979