GAMMA-GLUTAMYL-TRANSFERASE CYCLOTRANSFERASE - A NEW GENETIC-POLYMORPHISM IN THE MOUSE (MUS-MUSCULUS) LINKED TO LYT-2

  • 1 January 1981
    • journal article
    • research article
    • Vol. 99  (1) , 109-116
Abstract
Electrophoretically variant forms of .gamma.-glutamyl cyclotransferase were identified in red cells of inbred mouse strains. Each inbred strain exhibited a major band of activity and a minor band that migrated more anodally. The polymorphism affects the migration of both the major and minor bands in a similar way. F1 hybrids between strains with fast forms (A/J) and strains with the slow forms (C57BL/6J) exhibited a 4-banded pattern consistent with co-dominant inheritance. The patterns observed in backcross and F2 mice were consistent with the segregation of a pair of autosomal co-dominant alleles. Recombinant inbred strains and a congenic strain show that the locus controlling .gamma.-glutamyl cyclotransferase (Ggc) is linked to Lyt-2, a lymphocyte alloantigen locus on chromosome 6, with an estimated map distance of 5.0 .+-. 2.5 centimorgans.