Relationships between the effects of redox potential, α‐Thenoyltrifluoroacetone and malonate on O2− and H2O2 generation by submitochondrial particles in the presence of succinate and antimycin

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Abstract
The rate of the antimycin‐induced H2O2 and O2 XXXgeneration in beef heart submitochondrial particles is maximal at the [succinate]/[fumarate] ratio of 1:5 and decays at both higher and lower redox potentials. Succinate dehydrogenase inhibitors, such as TTFA or malonate, stimulate active oxygen production in the presence of excess succinate but are inhibitory at E h, values more positive than the optimal. The modulation of O2 xxx and H2O2 generation by these inhibitors can be explained by their effects on the steady‐state redox potential(s) of the component(s) of mitochondrial site 2.