SYNTHETIC MUSCLE RELAXANTS IN ANESTHESIA

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Abstract
Analgesia, amnesia or freedom from apprehension, and good muscular relaxation are essential in the anesthetic management of patients for most surgical procedures.1 Both ether and chloroform, the first two agents used extensively for the production of surgical anesthesia, were able to fulfill these three requirements. Due to this, for almost a century the search for new anesthetic agents was directed toward compounds that would possess all the three properties mentioned but would be free of the unwanted side-effects of ether and chloroform. In the middle 1930's, first cyclopropane2 and then thiopental (pentothal®) sodium3 were introduced into anesthesiology, and their use became rapidly popular. It soon became evident, however, that, with regard to muscular relaxation, neither cyclopropane nor thiopental sodium always fulfilled the requirements of good surgical anesthesia. While the search for new anesthetic agents continued, gradually more information had been gathered on the pharmacologic effects of the

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