Cytomegalovirus-induced immune suppression. II. Cell-mediated immunity.

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  • 1 September 1974
    • journal article
    • Vol. 18  (1) , 119-26
Abstract
Murine cytomegalovirus (CMV) causes depression of cell-mediated immunity. Skin graft survival is significantly prolonged across the strong H-2 and weak H-Y histocompatibility barriers in mice previously infected with CMV. Maximum prolongation of skin graft survival across the H-2 barrier occurred in mice infected on the day of grafting and survival was significantly prolonged in mice infected up to 5 days before grafting.