CLEARANCE AND IDENTIFICATION OF THYROTROPHIN RELEASING HORMONE IN HUMAN URINE AFTER INTRAVENOUS INJECTIONS
- 1 July 1975
- journal article
- Published by Wiley in Clinical Endocrinology
- Vol. 4 (4) , 421-426
- https://doi.org/10.1111/j.1365-2265.1975.tb01549.x
Abstract
The urine clearance of TRH after intravenous injection in man has been measured by radioimmunoassay. Between 4.4 percent and 10.7 percent of the dose was excreted within 90 min, the majority within 30 min. The TRH excreted was immunochemically and chromatographically indistinguishable from synthetic TRH and was inactivated by plasma enzymes with the same kinetic characteristics. The immunoreactive TRH-like material in basal urine samples was not TRH however: chromatographically and enzymatically it behaved differently from the synthetic tripeptide.Keywords
This publication has 8 references indexed in Scilit:
- THE INACTIVATION OF THYROTROPHIN RELEASING HORMONE BY PLASMA IN THYROID DISEASEClinical Endocrinology, 1975
- THE EFFECTS OF CALCITONIN AND PARATHORMONE ON PLASMA MAGNESIUM LEVELS BEFORE AND AFTER BIRTH IN THE RATJournal of Endocrinology, 1974
- BLOOD AND URINE CLEARANCE OF LUTEINIZING HORMONE RELEASING HORMONE IN MAN MEASURED BY RADIOIMMUNOASSAYJournal of Endocrinology, 1974
- USE OF BENZAMIDINE TO PREVENT THE DESTRUCTION OF THYROTROPIN-RELEASING HORMONE (TRH) BY BLOODJournal of Clinical Endocrinology & Metabolism, 1974
- RADIOIMMUNOASSAY OF THYROTROPHIN RELEASING HORMONEJournal of Endocrinology, 1973
- Factors in blood influencing the determination of thyrotropin releasing hormoneClinica Chimica Acta; International Journal of Clinical Chemistry, 1973
- ELIMINATION OF TRH IN MANJournal of Clinical Endocrinology & Metabolism, 1972
- Serum Inactivation of the Immunological and Biological Activity of Thyrotropin—Releasing Hormone (TRH)Endocrinology, 1972