THE EFFECT OF ISOPRENALINE ON PLASMA RENIN ACTIVITY IN MAN: A DOSE-RESPONSE CURVE

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Abstract
Four normal subjects on a free Na intake received i.v. isoprenaline in doses of 2, 4, 8 and 16 .mu.g over 2 min. Three of the subjects received a 2nd infusion of 8 .mu.g. The rate of renin release indexed by changes in plasma renin activity increased in all subjects at each dose level. Mean peak levels of plasma renin were 9, 29 and 77 above mean control levels at doses of 2, 4 and 8 .mu.g, respectively. The response of 16 .mu.g was no different from that seen with 8 .mu.g. The renin response obtained at 8 .mu.g was highly reproducible such that the coefficient of variation for duplicate estimations of plasma renin (12 duplicates) ranged from 1.7-4%.