Carbon-11 labelling of the antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and determination of plasma metabolites in man
- 1 April 1997
- journal article
- clinical trial
- Published by Elsevier in Applied Radiation and Isotopes
- Vol. 48 (4) , 487-492
- https://doi.org/10.1016/s0969-8043(96)00294-1
Abstract
No abstract availableKeywords
This publication has 11 references indexed in Scilit:
- Automated radiosyntheses of [6-O-methyl-11C]diprenorphine and [6-O-methyl-11C]buprenorphine from 3-O-trityl protected precursorsApplied Radiation and Isotopes, 1994
- Tumour pharmacokinetics?—we do need to knowThe Lancet, 1994
- In vitro assessment ofN-[2-(dimethylamino)ethyl]acridine-4-carboxamide, a DNA-intercalating antitumour drug with reduced sensitivity to multidrug resistanceCancer Chemotherapy and Pharmacology, 1993
- Pharmacokinetics of acridine-4-carboxamide in the rat, with extrapolation to humansCancer Chemotherapy and Pharmacology, 1993
- Comparison of the blood-brain barrier and liver penetration of acridine antitumor drugsCancer Chemotherapy and Pharmacology, 1992
- Pharmacokinetics and toxicity of the antitumour agentN-[2-(dimethylamino)ethyl]acridine-4-carboxamide after i.v. administration in the mouseCancer Chemotherapy and Pharmacology, 1992
- Design of NDA Intercalators To Overcome Topoisomerase II-Mediated Multidurg ResistanceJNCI Journal of the National Cancer Institute, 1990
- Selectivity of N-[2-(Dimethylamino)ethyl]acridine-4-car☐amide towards Lewis lung carcinoma and human tumour cell lines in vitroEuropean Journal of Cancer and Clinical Oncology, 1989
- Potential antitumor agents. 50. In vivo solid-tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamideJournal of Medicinal Chemistry, 1987
- Potential antitumor agents. Part 43. Synthesis and biological activity of dibasic 9-aminoacridine-4-carboxamides, a new class of antitumor agentJournal of Medicinal Chemistry, 1984