Continuous compact protein domains
- 1 January 1987
- journal article
- research article
- Published by Wiley in Proteins-Structure Function and Bioinformatics
- Vol. 2 (2) , 90-110
- https://doi.org/10.1002/prot.340020204
Abstract
The coefficient of compactness was recently introduced and used to locate domains in lysozyme and ribonuclease (Zehfus and Rose: Bio-chemistry 25:5759–5765, 1986). Nineteen additional proteins now have been analyzed by using this measure. Complete listings of compact units and plots showing their hierarchic organization are presented for all twenty-one proteins. Large compact units correspond well to protein domains; however, many smaller compact structures of equal or better compactness are also found. Since small compact units could represent subdomains or protein-folding intermediates, their structural composition is further examined.Keywords
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