Slate-Gray Color in Patients Receiving Chlorpromazine

Abstract
Five patients in a mental hospital developed a bluish coloration of exposed areas which resembled argyria. All were white women who had taken relatively large amounts (500 to 3,000 mg daily) of chlorpromazine for one to five years. Microscopically, the major abnormal finding was clumps of chromatophores in the dermis containing yellowish-brown pigment which had histochemical characteristics of melanin.

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