Cholera Toxin: Interaction of Subunits with Ganglioside G M1
- 15 February 1974
- journal article
- book review
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 183 (4125) , 656-657
- https://doi.org/10.1126/science.183.4125.656
Abstract
Vibrio cholerae exotoxin is an aggregate of two different noninterconvertible subunits (molecular weights about 15,000 and about 25,000). Only the smaller subunit reacts with ganglioside GM1, a possible biological receptor. The larger subunit, found only in active toxin molecules, can be eluted with 8 molar urea from insoluble complexes of toxin, ganglioside, and cerebroside.Keywords
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