Adrenergic sulfonanilides. 4. Centrally active .beta.-adrenergic agonists
- 30 April 1976
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 19 (5) , 626-633
- https://doi.org/10.1021/jm00227a010
Abstract
The CNS activities of a number of soterenol analogues were investigated [in the rat]. Several of these compounds possessed potent morphine antagonistic and anorexiant properties. The CNS activity of these compounds was enhanced by certain lipophilic [e.g., 1,1-dimethyl-2-phenethyl or cyclopropyl] N substituents; minor structural changes on either the aromatic or side-chain moieties drastically reduced central activity. Toxicity in this series was related to the inherent .alpha.-adrenergic stimulating component (direct or indirect).Keywords
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