LYMPHOBLASTIC LYMPHOMA IN ADULTS - RESULTS OF A PILOT PROTOCOL

  • 1 January 1981
    • journal article
    • research article
    • Vol. 57  (4) , 679-684
Abstract
Thirteen adult patients with histologically confirmed lymphoblastic lymphoma were treated with an intensive chemotherapy program consisting of induction with cyclophosphamide, adriamycin, vincristine and prednisone (modified CHOP); consolidation and CNS prophylaxis with methotrexate intrathecally and by high-dose i.v.injection, citrovorum factor and L-asparaginase; reinforcement with CHOP; and maintenance with 6-mercaptopurine and methotrexate. Treatment duration was 1 yr. A 14th patient with T cell acute lymphoblastic leukemia was also treated at presentation by the same regimen. Thirteen patients had at least a mediastinal mass or abnormal cells in the bone marrow; 1 presented with CNS disease. The median age was 22 yr (range 16-50) and male-female ratio was 2.5:1. All patients had a rapid complete clinical response. Of the 13 patients without initial CNS disease, 4 have relapsed, 3 with primary CNS relapse and one with a recurrent abdominal mass. Five patients have died, 2 from drug toxicity, 2 from CNS relapse and one from chronic myelogenous leukemia, which was diagnosed simultaneously with the lymphoblastic lymphoma. The median follow-up is 19 mo. and all patients have completed their planned therapy. At 3 yr, the actuarial survival is 61% and relapse-free survival is 56%.

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